BDBM22577 2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}-N-[(1S)-2-hydroxy-1-phenylethyl]acetamide::CHEMBL277006::alpha-substituted indomethacin ethanolamide, 17

SMILES COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(=O)N[C@H](CO)c3ccccc3)c2c1

InChI Key InChIKey=HBCGELQJRSFUJZ-XMMPIXPASA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 22577   

TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Michigan State University

LigandPNGBDBM22577(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50: <1.30E+3nMpH: 8.0 T: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test co mpounds for 20 min and then analyzed for remaining COX activity by t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Michigan State University

LigandPNGBDBM22577(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50:  85nMpH: 8.0 T: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test co mpounds for 20 min and then analyzed for remaining COX activity by t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Michigan State University

LigandPNGBDBM22577(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50: <1.30E+3nMAssay Description:Inhibitory concentration of the compound against wild type murine Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Michigan State University

LigandPNGBDBM22577(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50:  85nMAssay Description:Inhibitory concentration against human Prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Michigan State University

LigandPNGBDBM22577(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50:  85nMAssay Description:Inhibitory concentration against human prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed