BDBM226313 5-{6-(3-chlorophenyl)-8- [hydroxy(tetrahydro-2h- pyran-4-yl)methyl]-7- [(trans-4- methylcyclohexyl)methyl]- 7h-purin-2-yl}-1,3,4- oxadiazol-2(3h)-one (racemate)::US9540377, 23.1

SMILES C[C@H]1CC[C@H](Cn2c(C(O)C3CCOCC3)nc3nc(-c4n[nH]c(=O)o4)nc(-c4cccc(Cl)c4)c32)CC1

InChI Key InChIKey=BSSWWWFJLISFPV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 226313   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 226313BDBM226313(US9540377, 23.1 | 5-{6-(3-chlorophenyl)-8- [hydrox...)
Affinity DataIC50: 67.3nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent