BDBM226402 5-[6-(3-chlorophenyl)-7- [(trans-4- methylcyclohexyl)methyl]- 8-(tetrahydro-2h-pyran- 4-ylcarbonyl)-7h-purin-2- yl]-1,3,4-oxadiazol-2(3h)- one::US9540377, 23.9

SMILES C[C@H]1CC[C@H](Cn2c(C(=O)C3CCOCC3)nc3nc(-c4n[nH]c(=O)o4)nc(-c4cccc(Cl)c4)c32)CC1

InChI Key InChIKey=WCWYUHFDJFVAIJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 226402   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 226402BDBM226402(US9540377, 23.9 | 5-[6-(3-chlorophenyl)-7- [(trans...)
Affinity DataIC50: 24.6nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent