BDBM227689 3-{6-(5-chloropyridin-3- yl)-8-(3,4-dihydro-1h- isochromen-1-yl)-7- [(trans-4- methylcyclohexyl)methyl]- 7h-purin-2-yl}-1,2,4- oxadiazol-5(4h)-one (enantiomer 1)::US9540377, 23.104::US9540377, 23.105

SMILES C[C@H]1CC[C@H](Cn2c(C3OCCc4ccccc43)nc3nc(-c4noc(=O)[nH]4)nc(-c4cncc(Cl)c4)c32)CC1

InChI Key InChIKey=HJIQHBLJVWTOLN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 227689   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 227689BDBM227689(US9540377, 23.104 | US9540377, 23.105 | 3-{6-(5-ch...)
Affinity DataIC50: 1.03nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 227689BDBM227689(US9540377, 23.104 | US9540377, 23.105 | 3-{6-(5-ch...)
Affinity DataIC50: 2.16nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent