BDBM22784 1-chloro-2,3-dihydro-1H-indole-2,3-dione::Isatin-based compound, 4

SMILES ClN1C(=O)C(=O)c2ccccc12

InChI Key InChIKey=ZGPFGHSOYPBCGI-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 22784   

TargetLiver carboxylesterase 1(Rabbit)
St. Jude Research Hospital

LigandChemical structure of BindingDB Monomer ID 22784BDBM22784(1-chloro-2,3-dihydro-1H-indole-2,3-dione | Isatin-...)
Affinity DataKi:  4.83E+3nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Human)
St. Jude Research Hospital

LigandChemical structure of BindingDB Monomer ID 22784BDBM22784(1-chloro-2,3-dihydro-1H-indole-2,3-dione | Isatin-...)
Affinity DataKi:  2.28E+4nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
St. Jude Research Hospital

LigandChemical structure of BindingDB Monomer ID 22784BDBM22784(1-chloro-2,3-dihydro-1H-indole-2,3-dione | Isatin-...)
Affinity DataKi:  2.92E+4nM ΔG°:  -6.18kcal/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
St. Jude Research Hospital

LigandChemical structure of BindingDB Monomer ID 22784BDBM22784(1-chloro-2,3-dihydro-1H-indole-2,3-dione | Isatin-...)
Affinity DataKi: >1.00E+5nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCholinesterase(Human)
St. Jude Research Hospital

LigandChemical structure of BindingDB Monomer ID 22784BDBM22784(1-chloro-2,3-dihydro-1H-indole-2,3-dione | Isatin-...)
Affinity DataKi: >1.00E+5nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed