BDBM22979 CHEMBL148629::Meclofenamic acid derivative, 31::methyl 2-({2-[(2,6-dichloro-3-methylphenyl)amino]phenyl}formamido)acetate

SMILES COC(=O)CNC(=O)c1ccccc1Nc1c(Cl)ccc(C)c1Cl

InChI Key InChIKey=YMFGAYPNXNJNBI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 22979   

TargetProstaglandin G/H synthase 1(Sheep)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM22979(CHEMBL148629 | methyl 2-({2-[(2,6-dichloro-3-methy...)
Affinity DataIC50: 70nMAssay Description:Inhibition of the ovine Prostaglandin G/H synthase 1 was determined by thin-layer chromatography assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Vanderbilt University School of Medicine

LigandPNGBDBM22979(CHEMBL148629 | methyl 2-({2-[(2,6-dichloro-3-methy...)
Affinity DataIC50: 70nMT: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test compounds for 20 min and then analyzed for remaining COX activity by tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2008
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Vanderbilt University School of Medicine

LigandPNGBDBM22979(CHEMBL148629 | methyl 2-({2-[(2,6-dichloro-3-methy...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of the human Prostaglandin G/H synthase 2 was determined by thin-layer chromatography assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM22979(CHEMBL148629 | methyl 2-({2-[(2,6-dichloro-3-methy...)
Affinity DataIC50: 1.20E+3nMpH: 8.0 T: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test compounds for 20 min and then analyzed for remaining COX activity by tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2008
Entry Details Article
PubMed