BDBM233018 N-{4-[2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)ethoxy]phenyl}imidodicarbonimidic diamide hydrochloride (A1-01)

SMILES NC(=N)NC(=N)Nc1ccc(OCCN2C(=O)c3ccccc3C2=O)cc1

InChI Key InChIKey=CAOSWQOXGYNTLJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 233018   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Institute of Chemical Technology

LigandPNGBDBM233018(N-{4-[2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)et...)
Affinity DataIC50: 4.03E+4nMAssay Description:The synthesized compounds were evaluated for their ability to inhibit DHFR from pc, tg, ma, and rl using a continuous spectrophotometric assay measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2017
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Institute of Chemical Technology

LigandPNGBDBM233018(N-{4-[2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)et...)
Affinity DataIC50: 5.14E+4nMAssay Description:The synthesized compounds were evaluated for their ability to inhibit DHFR from pc, tg, ma, and rl using a continuous spectrophotometric assay measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2017
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Institute of Chemical Technology

LigandPNGBDBM233018(N-{4-[2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)et...)
Affinity DataIC50: 5.14E+4nMAssay Description:The synthesized compounds were evaluated for their ability to inhibit DHFR from pc, tg, ma, and rl using a continuous spectrophotometric assay measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2017
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Institute of Chemical Technology

LigandPNGBDBM233018(N-{4-[2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)et...)
Affinity DataIC50: 6.77E+4nMAssay Description:The synthesized compounds were evaluated for their ability to inhibit DHFR from pc, tg, ma, and rl using a continuous spectrophotometric assay measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2017
Entry Details Article
PubMed