BDBM234387 10-(2-N,N-Dimethylaminoethoxy)-5-Thia-4-b-azaindeno[2,1-a]indene-5,5-Dioxide (8a)

SMILES CN(C)CCOc1c2-c3ccccc3S(=O)(=O)n2c2ccccc12

InChI Key InChIKey=PWFDILKXFQTPQW-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 234387   

TargetCytochrome P450 2D6(Human)
Suven Life Sciences

LigandPNGBDBM234387(10-(2-N,N-Dimethylaminoethoxy)-5-Thia-4-b-azainden...)
Affinity DataIC50: 7.65E+3nMAssay Description:The cytochrome P450 inhibitory potential was determined using isoform-selective assays and heterologously expressed human CYP2D6 and CYP3A4.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Suven Life Sciences

LigandPNGBDBM234387(10-(2-N,N-Dimethylaminoethoxy)-5-Thia-4-b-azainden...)
Affinity DataIC50: 1.00E+4nMAssay Description:Muscarinic acetylcholine receptor M1 was cloned into an expression vector and transfected in CHO cells along with CRE-Luc reporter system. Isolated c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Suven Life Sciences

LigandPNGBDBM234387(10-(2-N,N-Dimethylaminoethoxy)-5-Thia-4-b-azainden...)
Affinity DataIC50: 1.00E+4nMAssay Description:Recombinant CHO cells were established by transfecting an expression vector encoding human 5-HT4a gene and CRE-Luc reporter system. Isolated colonies...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
Suven Life Sciences

LigandPNGBDBM234387(10-(2-N,N-Dimethylaminoethoxy)-5-Thia-4-b-azainden...)
Affinity DataIC50: 1.00E+4nMAssay Description:CHO cells were transfected with an expression vector encoding rat 5-HT7 gene and CRE-Luc reporter system. Colonies were isolated and screened with 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Suven Life Sciences

LigandPNGBDBM234387(10-(2-N,N-Dimethylaminoethoxy)-5-Thia-4-b-azainden...)
Affinity DataIC50: 4.50E+4nMAssay Description:The cytochrome P450 inhibitory potential was determined using isoform-selective assays and heterologously expressed human CYP2D6 and CYP3A4.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed