BDBM236643 US9388139, 12
SMILES CC(C)(C)C1=NN(C(C1)c1ccc(Cl)cc1Cl)c1ccc(cc1)C(O)=O
InChI Key InChIKey=DIZHQHRVPINGBC-UHFFFAOYSA-N
Data 16 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 16 hits for monomerid = 236643
Affinity DataIC50: 3.70E+3nMAssay Description:PDE activity was measured using the IMAP fluorescence polarization assay (Molecular Devices) in which binding of hydrolyzed cyclic nucleotide substra...More data for this Ligand-Target Pair
TargetIsoform 4 of Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (PDE11A1)(Homo sapiens (Human))
German University
US Patent
German University
US Patent
Affinity DataIC50: >5.00E+4nMAssay Description:PDE activity was measured using the IMAP fluorescence polarization assay (Molecular Devices) in which binding of hydrolyzed cyclic nucleotide substra...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:The activities of COX-1 and COX-2 were measured after the addition of arachidonic acid and incubation at 25° C. for 5 min by absorbance at 590 nm as ...More data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
German University
US Patent
German University
US Patent
Affinity DataIC50: >5.00E+4nMAssay Description:PDE activity was measured using the IMAP fluorescence polarization assay (Molecular Devices) in which binding of hydrolyzed cyclic nucleotide substra...More data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
German University
US Patent
German University
US Patent
Affinity DataIC50: >5.00E+4nMAssay Description:PDE activity was measured using the IMAP fluorescence polarization assay (Molecular Devices) in which binding of hydrolyzed cyclic nucleotide substra...More data for this Ligand-Target Pair
TargetIsoform PDE2A1 of cGMP-dependent 3',5'-cyclic phosphodiesterase (PDE2A1)(Homo sapiens (Human))
German University
US Patent
German University
US Patent
Affinity DataIC50: >5.00E+4nMAssay Description:PDE activity was measured using the IMAP fluorescence polarization assay (Molecular Devices) in which binding of hydrolyzed cyclic nucleotide substra...More data for this Ligand-Target Pair
TargetIsoform PDE2A1 of cGMP-dependent 3',5'-cyclic phosphodiesterase (PDE2A1)(Homo sapiens (Human))
German University
US Patent
German University
US Patent
Affinity DataIC50: >5.00E+4nMAssay Description:PDE activity was measured using the IMAP fluorescence polarization assay (Molecular Devices) in which binding of hydrolyzed cyclic nucleotide substra...More data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
German University
US Patent
German University
US Patent
Affinity DataIC50: >5.00E+4nMAssay Description:PDE activity was measured using the IMAP fluorescence polarization assay (Molecular Devices) in which binding of hydrolyzed cyclic nucleotide substra...More data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
German University
US Patent
German University
US Patent
Affinity DataIC50: >5.00E+4nMAssay Description:PDE activity was measured using the IMAP fluorescence polarization assay (Molecular Devices) in which binding of hydrolyzed cyclic nucleotide substra...More data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
German University
US Patent
German University
US Patent
Affinity DataIC50: >5.00E+4nMAssay Description:PDE activity was measured using the IMAP fluorescence polarization assay (Molecular Devices) in which binding of hydrolyzed cyclic nucleotide substra...More data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
German University
US Patent
German University
US Patent
Affinity DataIC50: >5.00E+4nMAssay Description:PDE activity was measured using the IMAP fluorescence polarization assay (Molecular Devices) in which binding of hydrolyzed cyclic nucleotide substra...More data for this Ligand-Target Pair
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
German University
US Patent
German University
US Patent
Affinity DataIC50: >5.00E+4nMAssay Description:PDE activity was measured using the IMAP fluorescence polarization assay (Molecular Devices) in which binding of hydrolyzed cyclic nucleotide substra...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
German University
US Patent
German University
US Patent
Affinity DataIC50: >5.00E+4nMAssay Description:PDE activity was measured using the IMAP fluorescence polarization assay (Molecular Devices) in which binding of hydrolyzed cyclic nucleotide substra...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
German University
US Patent
German University
US Patent
Affinity DataIC50: >5.00E+4nMAssay Description:PDE activity was measured using the IMAP fluorescence polarization assay (Molecular Devices) in which binding of hydrolyzed cyclic nucleotide substra...More data for this Ligand-Target Pair
TargetIsoform 4 of Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (PDE11A1)(Homo sapiens (Human))
German University
US Patent
German University
US Patent
Affinity DataIC50: >5.00E+4nMAssay Description:PDE activity was measured using the IMAP fluorescence polarization assay (Molecular Devices) in which binding of hydrolyzed cyclic nucleotide substra...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:The activities of COX-1 and COX-2 were measured after the addition of arachidonic acid and incubation at 25° C. for 5 min by absorbance at 590 nm as ...More data for this Ligand-Target Pair