BDBM23887 3-amidinophenylalanine deriv., 31::4-({4-[(2S)-3-(3-carbamimidoylphenyl)-2-{[2,4,6-tris(propan-2-yl)benzene]sulfonamido}propanoyl]piperazin-1-yl}carbonyl)piperidine-1-carboximidamide

SMILES CC(C)c1cc(C(C)C)c(c(c1)C(C)C)S(=O)(=O)N[C@@H](Cc1cccc(c1)C(N)=N)C(=O)N1CCN(CC1)C(=O)C1CCN(CC1)C(N)=N

InChI Key InChIKey=KSEVHDWJTMMENT-HKBQPEDESA-N

Data  8 KI

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 23887   

TargetSuppressor of tumorigenicity 14 protein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM23887(3-amidinophenylalanine deriv., 31 | 4-({4-[(2S)-3-...)
Affinity DataKi:  4.30nMAssay Description:Inhibition of matripase (unknown origin) using Boc-QAR-AMC as substrate incubated for 30 mins prior to substrate addition by fluorescence assayMore data for this Ligand-Target Pair
TargetSuppressor of tumorigenicity 14 protein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM23887(3-amidinophenylalanine deriv., 31 | 4-({4-[(2S)-3-...)
Affinity DataKi:  14nM ΔG°:  -10.7kcal/molepH: 8.0 T: 2°CAssay Description:The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used. Af...More data for this Ligand-Target Pair
TargetPlasminogen(Homo sapiens (Human))
Curacyte Chemistry

LigandPNGBDBM23887(3-amidinophenylalanine deriv., 31 | 4-({4-[(2S)-3-...)
Affinity DataKi:  600nMAssay Description:The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used. Af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Curacyte Chemistry

LigandPNGBDBM23887(3-amidinophenylalanine deriv., 31 | 4-({4-[(2S)-3-...)
Affinity DataKi:  1.10E+3nMAssay Description:The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used. Af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease hepsin(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM23887(3-amidinophenylalanine deriv., 31 | 4-({4-[(2S)-3-...)
Affinity DataKi:  1.58E+3nMAssay Description:Inhibition of hepsin (unknown origin) using Boc-QAR-AMC as substrate after 30 mins prior to substrate addition by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Curacyte Chemistry

LigandPNGBDBM23887(3-amidinophenylalanine deriv., 31 | 4-({4-[(2S)-3-...)
Affinity DataKi:  5.00E+3nMAssay Description:The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used. Af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Bos taurus)
Curacyte Chemistry

LigandPNGBDBM23887(3-amidinophenylalanine deriv., 31 | 4-({4-[(2S)-3-...)
Affinity DataKi:  1.00E+4nMAssay Description:The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used. Af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor activator(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM23887(3-amidinophenylalanine deriv., 31 | 4-({4-[(2S)-3-...)
Affinity DataKi:  1.70E+4nMAssay Description:Inhibition of recombinant N-terminal His-tagged HGFA (unknown origin) expressed in baculovirus-infected Sf9 cells using Boc-QLR-AMC as substrate incu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed