BDBM239792 Roche-Dataset for PDE10A, Compound 584::US9394311, 75

SMILES CCc1cnc(n2c1nc(n2)CCc3nc(nn3C)N4CCCC4)C

InChI Key InChIKey=GCXBODMFGFPZET-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 239792   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
F. Hoffmann-La Roche

LigandBDBM239792(US9394311, 75 | Roche-Dataset for PDE10A, Compound...)Copy SMILESCopy InChI

Affinity DataIC50: 2.86nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In Depth
Date in BDB:
10/28/2022
Entry Details Article
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TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
F. Hoffmann-La Roche

LigandBDBM239792(US9394311, 75 | Roche-Dataset for PDE10A, Compound...)Copy SMILESCopy InChI

Affinity DataIC50: 3.78nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In Depth
Date in BDB:
7/31/2017
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL