BDBM244217 (r)-5,5-dimethyl-2-(phenylamino)-n-(1-phenylethyl)-5h-pyrrolo[3,4-d]pyrimidine-6(7h)-carboxamide::US9546173, cmpd 156::US9546173, cmpd 169

SMILES CC(NC(=O)N1Cc2nc(Nc3ccccc3)ncc2C1(C)C)c1ccccc1

InChI Key InChIKey=MEMAFGFDKNYDBP-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 244217   

TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM244217((r)-5,5-dimethyl-2-(phenylamino)-n-(1-phenylethyl)...)
Affinity DataIC50:  117nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM244217((r)-5,5-dimethyl-2-(phenylamino)-n-(1-phenylethyl)...)
Affinity DataIC50:  3.53E+4nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM244217((r)-5,5-dimethyl-2-(phenylamino)-n-(1-phenylethyl)...)
Affinity DataIC50: >2.50E+4nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM244217((r)-5,5-dimethyl-2-(phenylamino)-n-(1-phenylethyl)...)
Affinity DataIC50:  2.57E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRibosomal protein S6 kinase alpha-1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM244217((r)-5,5-dimethyl-2-(phenylamino)-n-(1-phenylethyl)...)
Affinity DataIC50:  3.60E+3nMAssay Description:Lists compounds that were tested for inhibition of RSK; the IC50 values are in micromolar units, and refer to inhibition of RSK1 and RSK2, respective...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent