BDBM244400 US10226449, cpd 9::US9428502, 9

SMILES COCc1nc(C)c([nH]1)-c1cc(ccc1C1CCC1)C(=O)N1CCC(CC1)c1ccc(cc1)C#N

InChI Key InChIKey=DJFUTKZRAWSOJN-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 244400   

TargetFatty acid synthase(Human)
3-V Biosciences

US Patent
LigandPNGBDBM244400(US9428502, 9 | US10226449, cpd 9)
Affinity DataIC50: 25nMAssay Description:FASN activity of the SKBr3 cell extract was determined by measuring either NADPH oxidation or the amount of thiol-containing coenzyme A (CoA) release...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetGenome polyprotein(HCV)
3-V Biosciences

US Patent
LigandPNGBDBM244400(US9428502, 9 | US10226449, cpd 9)
Affinity DataEC50:  30nMAssay Description:The antiviral activities of the compounds were assessed using the HCV1b replicon system. The replicon was constructed using the ET (luc-ubi-neo/ET) c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetFatty acid synthase(Human)
3-V Biosciences

US Patent
LigandPNGBDBM244400(US9428502, 9 | US10226449, cpd 9)
Affinity DataIC50: 25nMT: 2°CAssay Description:The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels of FASN expression. It is estimated that FAS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
US Patent