BDBM244722 US10226449, cpd 332::US9428502, 332

SMILES Cc1ccc(C(=O)N2CC(c3ccc(C#N)cc3)C2)cc1-c1[nH]c(C2CCC(O)CC2)nc1C

InChI Key InChIKey=BRJYPRNAXRATDU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 244722   

TargetFatty acid synthase(Human)
3-V Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 244722BDBM244722(US9428502, 332 | US10226449, cpd 332 | US202500179...)
Affinity DataIC50: 10nMT: 2°CAssay Description:The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels of FASN expression. It is estimated that FAS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
US Patent

TargetFatty acid synthase(Human)
3-V Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 244722BDBM244722(US9428502, 332 | US10226449, cpd 332 | US202500179...)
Affinity DataIC50: 10nMAssay Description:FASN activity of the SKBr3 cell extract was determined by measuring either NADPH oxidation or the amount of thiol-containing coenzyme A (CoA) release...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetFatty acid synthase(Human)
3-V Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 244722BDBM244722(US9428502, 332 | US10226449, cpd 332 | US202500179...)
Affinity DataIC50: 10nMAssay Description:Determination of FASN biochemical activity: The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent