BDBM244916 US9422293, 142::US9738649, Example 142

SMILES CC(C)c1nc2CCN(CCc2c(Nc2ccc(cc2)-c2cnco2)n1)c1ncccc1C(F)(F)F

InChI Key InChIKey=SKTRXKMFBQBEBU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 244916   

TargetTransient receptor potential cation channel subfamily V member 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM244916(US9422293, 142 | US9738649, Example 142)
Affinity DataIC50: 1.66E+3nMAssay Description:HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2019
Entry Details
Go to US Patent

TargetTransient receptor potential cation channel subfamily V member 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM244916(US9422293, 142 | US9738649, Example 142)
Affinity DataIC50: 1.66E+3nMT: 2°CAssay Description:HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
Go to US Patent

LigandPNGBDBM244916(US9422293, 142 | US9738649, Example 142)
Affinity DataIC50: 2.09E+3nMAssay Description:The assay was performed as described above, using HEK293 cells transfected with rat TRPV1 (rTRPV1/HEK293). These cells had a geneticin selection mark...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2019
Entry Details
Go to US Patent

LigandPNGBDBM244916(US9422293, 142 | US9738649, Example 142)
Affinity DataIC50: 2.09E+3nMT: 2°CAssay Description:The assay was performed as described below, using HEK293 cells transfected with rat TRPV1 (rTRPV1/HEK293). These cells had a geneticin selection mark...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
Go to US Patent