BDBM245228 US9428500, 22

SMILES CN1CCC(CC1)N1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(\C=C\c4ccccc4C(F)(F)F)c3c2c1

InChI Key InChIKey=FGMUABGJGHKPSH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 245228   

TargetALK tyrosine kinase receptor(Human)
University of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM245228(US9428500, 22)
Affinity DataIC50: 880nMAssay Description:Inhibition of recombinant GST-tagged ALK L1196M mutant (1064 to 1427 residues) (unknown origin) expressed in Sf9 cells using TMB peptide as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetALK tyrosine kinase receptor [L1196M](Human)
Universita Degli Studi Di Milano—Bicocca

US Patent
LigandPNGBDBM245228(US9428500, 22)
Affinity DataIC50: 880nMpH: 7.5 T: 2°CAssay Description:GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
US Patent

TargetALK tyrosine kinase receptor(Human)
University of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM245228(US9428500, 22)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of recombinant GST-tagged wild type ALK (1064 to 1427 residues) (unknown origin) expressed in Sf9 cells using TMB peptide as substrate pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM245228(US9428500, 22)
Affinity DataIC50: 2.90E+3nMpH: 7.5 T: 2°CAssay Description:GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
US Patent