BDBM245482 US9428503, 9
SMILES CN(C)CCCOc1ccc(cn1)-c1cc2c3n(C4COC4)c(=O)n(C)c3cnc2cc1F
InChI Key InChIKey=YHUHZZWORFKBEO-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 245482
Affinity DataIC50: 3.80nMT: 2°CAssay Description:Assay a) HT29 cells (ECACC #85061109) were seeded into 384 well assay plates (Costar #3712) at a density of 3500 cells/well in 40 μl EMEM medium c...More data for this Ligand-Target Pair
Affinity DataIC50: >2.13E+4nMT: 2°CAssay Description:Assay d) MDA-MB-468 cells (human breast adenocarcinoma ##ATCC HTB 132) were seeded at 1500 cells/well in 40 μl of DMEM containing 10% FBS and 1% g...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Astrazeneca
US Patent
Astrazeneca
US Patent
Affinity DataIC50: >2.91E+4nMT: 2°CAssay Description:Assay c) BT474 cells (human breast ductal carcinoma, ATCC HTB-20) were seeded into black 384 well plates (Costar, #3712) at a density of 5600 cells/w...More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMT: 2°CAssay Description:Assay b) HT29 cells (ECACC #85061109) were seeded into 384 well assay plates (Costar #3712) at a density of 6000 cells/well in 40 μl EMEM medium c...More data for this Ligand-Target Pair