BDBM245717 US9428511, 9

SMILES C[C@@H]1CN(C[C@@H]1Nc1c(cnn2cc(nc12)-c1cnn(CC(C)(C)O)c1)C(N)=O)c1nnc(s1)C(F)(F)F

InChI Key InChIKey=PIWKYJPKXLBMEH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 245717   

TargetTyrosine-protein kinase JAK3(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM245717(US9428511, 9)
Affinity DataIC50: 3.10nMpH: 7.4 T: 2°CAssay Description:The assay reactions were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2017
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM245717(US9428511, 9)
Affinity DataIC50: 6.90nMpH: 7.4 T: 2°CAssay Description:The assay reactions were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2017
Entry Details
Go to US Patent