BDBM24767 5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-2-[(2-fluorophenyl)amino]-3-methyl-3,4-dihydropyrimidin-4-one::pyrimidone, 49

SMILES COc1cc2nccc(Oc3ccc(cc3F)-c3cnc(Nc4ccccc4F)n(C)c3=O)c2cc1OC

InChI Key InChIKey=QZCOGTMXBBPDKK-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 24767   

TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

LigandPNGBDBM24767(5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophe...)
Affinity DataKi:  45nM ΔG°:  -9.91kcal/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

LigandPNGBDBM24767(5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophe...)
Affinity DataIC50:  45nMAssay Description:Inhibition of human c-METMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed