BDBM254128 US10112937, Example 2::US10150765, Example 2::US10703749, Example 2::US9464084, 2

SMILES FC(F)(F)c1cccc(C(=O)N2CCc3c(C2)ncn3-c2ccccc2)c1Cl

InChI Key InChIKey=CVNKYCMMEPEVGH-UHFFFAOYSA-N

Data  5 KI  12 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 254128   

TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL

LigandBDBM254128(US9464084, 2 | US10112937, Example 2 | US10150765,...)Copy SMILESCopy InChI

Affinity DataIC50: 12nMAssay Description:Antagonist activity at recombinant human P2X7 receptor expressed in human 1321N1 cells assessed as inhibition of Bz-ATP-induced Ca2+ flux preincubate...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
7/5/2018
Entry Details Article
Copy BDB DOIPubMed
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TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL

LigandBDBM254128(US9464084, 2 | US10112937, Example 2 | US10150765,...)Copy SMILESCopy InChI

Affinity DataIC50: 12.1nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/4/2019
Entry Details
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TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL

LigandBDBM254128(US9464084, 2 | US10112937, Example 2 | US10150765,...)Copy SMILESCopy InChI

Affinity DataIC50: 18.4nMAssay Description:1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/9/2019
Entry Details
Copy BDB DOIUS Patent

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TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL

LigandBDBM254128(US9464084, 2 | US10112937, Example 2 | US10150765,...)Copy SMILESCopy InChI

Affinity DataIC50: 18.4nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/4/2019
Entry Details
Copy BDB DOIUS Patent

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TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL

LigandBDBM254128(US9464084, 2 | US10112937, Example 2 | US10150765,...)Copy SMILESCopy InChI

Affinity DataIC50: 18.4nMpH: 7.4Assay Description:1321 N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glu...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/16/2017
Entry Details
Copy BDB DOIUS Patent

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TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL

LigandBDBM254128(US9464084, 2 | US10112937, Example 2 | US10150765,...)Copy SMILESCopy InChI

Affinity DataIC50: 18.4nMAssay Description:Human or rat P2X7-1321 N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/8/2021
Entry Details
Copy BDB DOIUS Patent

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TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL

LigandBDBM254128(US9464084, 2 | US10112937, Example 2 | US10150765,...)Copy SMILESCopy InChI

Affinity DataKi:  87.1nMAssay Description:Human or rat P2X7-1321N1 cells were collected and frozen @ −80° C. On the day of the experiment, cell membrane preparations were made according...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/9/2019
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL

LigandBDBM254128(US9464084, 2 | US10112937, Example 2 | US10150765,...)Copy SMILESCopy InChI

Affinity DataKi:  87.1nMAssay Description:human or rat P2X7-1321 N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/16/2017
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL

LigandBDBM254128(US9464084, 2 | US10112937, Example 2 | US10150765,...)Copy SMILESCopy InChI

Affinity DataKi:  87.1nMAssay Description:uman or rat P2X7-1321N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/4/2019
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL

LigandBDBM254128(US9464084, 2 | US10112937, Example 2 | US10150765,...)Copy SMILESCopy InChI

Affinity DataKi:  87.1nMAssay Description:Human or rat P2X7-1321 N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/8/2021
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL

LigandBDBM254128(US9464084, 2 | US10112937, Example 2 | US10150765,...)Copy SMILESCopy InChI

Affinity DataKi:  87.1nMAssay Description:uman or rat P2X7-1321N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/4/2019
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent

LigandBDBM254128(US9464084, 2 | US10112937, Example 2 | US10150765,...)Copy SMILESCopy InChI

Affinity DataIC50: 1.94E+3nMpH: 7.4Assay Description:1321 N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glu...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/16/2017
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent

LigandBDBM254128(US9464084, 2 | US10112937, Example 2 | US10150765,...)Copy SMILESCopy InChI

Affinity DataIC50: 1.94E+3nMAssay Description:1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/9/2019
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent

LigandBDBM254128(US9464084, 2 | US10112937, Example 2 | US10150765,...)Copy SMILESCopy InChI

Affinity DataIC50: 1.94E+3nMAssay Description:Human or rat P2X7-1321 N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/8/2021
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent

LigandBDBM254128(US9464084, 2 | US10112937, Example 2 | US10150765,...)Copy SMILESCopy InChI

Affinity DataIC50: 1.94E+3nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/4/2019
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent

LigandBDBM254128(US9464084, 2 | US10112937, Example 2 | US10150765,...)Copy SMILESCopy InChI

Affinity DataIC50: 2.91E+3nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/4/2019
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent

LigandBDBM254128(US9464084, 2 | US10112937, Example 2 | US10150765,...)Copy SMILESCopy InChI

Affinity DataIC50: 2.91E+3nMAssay Description:Antagonist activity at recombinant rat P2X7 receptor expressed in human 1321N1 cells assessed as inhibition of Bz-ATP-induced Ca2+ flux preincubated ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
7/5/2018
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL