BDBM25444 6-(3-fluoro-4-methoxyphenyl)-1-(pyridin-4-yl)-1,2,3,4-tetrahydronaphthalen-1-ol::Abiraterone mimetic, 7

SMILES COc1ccc(cc1F)-c1ccc2c(CCCC2(O)c2ccncc2)c1

InChI Key InChIKey=LRECNGBVUUBJSA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 25444   

TargetCytochrome P450 11B1, mitochondrial(Human)
Saarland University

LigandPNGBDBM25444(6-(3-fluoro-4-methoxyphenyl)-1-(pyridin-4-yl)-1,2,...)
Affinity DataIC50: 686nMAssay Description:The 17 alpha-hydroxylase activity of CYP 17 was determined by measuring the conversion of progesterone into 17 alpha-hydroxyprogesterone and the bypr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Saarland University

LigandPNGBDBM25444(6-(3-fluoro-4-methoxyphenyl)-1-(pyridin-4-yl)-1,2,...)
Affinity DataIC50: 945nMAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Saarland University

LigandPNGBDBM25444(6-(3-fluoro-4-methoxyphenyl)-1-(pyridin-4-yl)-1,2,...)
Affinity DataIC50: 5.00E+3nMpH: 7.4 T: 2°CAssay Description:The 17 alpha-hydroxylase activity of CYP 17 was determined by measuring the conversion of progesterone into 17 alpha-hydroxyprogesterone and the bypr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Saarland University

LigandPNGBDBM25444(6-(3-fluoro-4-methoxyphenyl)-1-(pyridin-4-yl)-1,2,...)
Affinity DataIC50: 1.52E+4nMAssay Description:The 17 alpha-hydroxylase activity of CYP 17 was determined by measuring the conversion of progesterone into 17 alpha-hydroxyprogesterone and the bypr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed