BDBM254983 US9475813, 39

SMILES CN(C)C[C@H]1CC[C@H](N2CNC(=O)c3cnc4[nH]ccc4c32)CC1

InChI Key InChIKey=UXZLCNQSQUXGBS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 254983   

TargetTyrosine-protein kinase JAK1(Human)
Nissan Chemical Industries

US Patent
LigandChemical structure of BindingDB Monomer ID 254983BDBM254983(US9475813, 39)
Affinity DataIC50: 11nMAssay Description:The inhibitory activity of the compounds of the present invention against JAK was measured.The respective enzymes (JAK1, JAK2, JAK3 and Tyk2) were pu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2017
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nissan Chemical Industries

US Patent
LigandChemical structure of BindingDB Monomer ID 254983BDBM254983(US9475813, 39)
Affinity DataIC50: 69nMAssay Description:The inhibitory activity of the compounds of the present invention against JAK was measured.The respective enzymes (JAK1, JAK2, JAK3 and Tyk2) were pu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2017
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nissan Chemical Industries

US Patent
LigandChemical structure of BindingDB Monomer ID 254983BDBM254983(US9475813, 39)
Affinity DataIC50: 200nMAssay Description:The inhibitory activity of the compounds of the present invention against JAK was measured.The respective enzymes (JAK1, JAK2, JAK3 and Tyk2) were pu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2017
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Nissan Chemical Industries

US Patent
LigandChemical structure of BindingDB Monomer ID 254983BDBM254983(US9475813, 39)
Affinity DataIC50: 490nMAssay Description:The inhibitory activity of the compounds of the present invention against JAK was measured.The respective enzymes (JAK1, JAK2, JAK3 and Tyk2) were pu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2017
Entry Details
US Patent