BDBM255381 US9481682, 132

SMILES COc1cc(C(=O)Nc2cc(ccn2)C(F)(F)F)c(F)cc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2c(Cl)cnc(N)c12

InChI Key InChIKey=ZKCHRFCIUPMISW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 255381   

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM255381(US9481682, 132)
Affinity DataIC50: 1.20nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2017
Entry Details
US Patent