BDBM25567 2,6-Disubstituted Pyrazine, 9::ethyl 3-{6-[(3,4,5-trimethoxyphenyl)amino]pyrazin-2-yl}benzoate

SMILES CCOC(=O)c1cccc(c1)-c1cncc(Nc2cc(OC)c(OC)c(OC)c2)n1

InChI Key InChIKey=LAUOTLUUDUQZKV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 25567   

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25567(ethyl 3-{6-[(3,4,5-trimethoxyphenyl)amino]pyrazin-...)
Affinity DataIC50: 1.40E+4nMpH: 7.2 T: 2°CAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed