BDBM2588 3,4-bis(1H-indol-3-yl)-2,5-dihydrofuran-2,5-dione::Bisindolyl deriv. 5::Bisindolylmaleimide deriv. 10

SMILES O=C1OC(=O)C(=C1c1c[nH]c2ccccc12)c1c[nH]c2ccccc12

InChI Key InChIKey=BEDSOEWYLAPDOL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 2588   

LigandPNGBDBM2588(3,4-bis(1H-indol-3-yl)-2,5-dihydrofuran-2,5-dione ...)
Affinity DataIC50: 5.00E+4nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2004
Entry Details
PubMed
TargetProtein kinase C beta type(Rat)
Roche Products

LigandPNGBDBM2588(3,4-bis(1H-indol-3-yl)-2,5-dihydrofuran-2,5-dione ...)
Affinity DataIC50: 1.00E+5nMpH: 7.5 T: 2°CAssay Description:The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2004
Entry Details Article
PubMed