BDBM259184 US9499502, 27bs-b
SMILES C[C@]1(CS(=O)(=O)[C@@](C)(C(=N)N1)c1ccccc1F)c1sc(cc1F)-c1cccc(c1)C#N
InChI Key InChIKey=WJAPMRNJIJYRHN-XZOQPEGZSA-N
Data 2 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 259184
Affinity DataKi: 1.02E+3nM ΔG°: -8.31kcal/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEVN...More data for this Ligand-Target Pair
Affinity DataKi: 3.17E+3nM ΔG°: -7.62kcal/molepH: 5.0 T: 2°CAssay Description:A homogeneous time-resolved FRET assay can be used to determine IC50 values for inhibitors of the soluble human BACE1 catalytic domain. This assay mo...More data for this Ligand-Target Pair