BDBM259184 US9499502, 27bs-b

SMILES C[C@]1(CS(=O)(=O)[C@@](C)(C(=N)N1)c1ccccc1F)c1sc(cc1F)-c1cccc(c1)C#N

InChI Key InChIKey=WJAPMRNJIJYRHN-XZOQPEGZSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 259184   

TargetBeta-secretase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM259184(US9499502, 27bs-b)
Affinity DataKi:  1.02E+3nM ΔG°:  -8.31kcal/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEVN...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM259184(US9499502, 27bs-b)
Affinity DataKi:  3.17E+3nM ΔG°:  -7.62kcal/molepH: 5.0 T: 2°CAssay Description:A homogeneous time-resolved FRET assay can be used to determine IC50 values for inhibitors of the soluble human BACE1 catalytic domain. This assay mo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent