BDBM259333 US9505745, 10::US9790212, Example 10

SMILES Cc1cc(C)c(CNC(=O)c2cnn(CC3CCOCC3)c2C)c(=O)[nH]1

InChI Key InChIKey=NEGOYFGGWMLPMB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 259333   

LigandChemical structure of BindingDB Monomer ID 259333BDBM259333(US9505745, 10 | US9790212, Example 10)
Affinity DataIC50: 1.58E+4nMAssay Description:Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 259333BDBM259333(US9505745, 10 | US9790212, Example 10)
Affinity DataIC50: 1.58E+4nMAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 259333BDBM259333(US9505745, 10 | US9790212, Example 10)
Affinity DataIC50: 1.00E+5nMAssay Description:Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 259333BDBM259333(US9505745, 10 | US9790212, Example 10)
Affinity DataIC50: 1.00E+5nMAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
US Patent