BDBM259346 US9505745, 23::US9790212, Example 23

SMILES Cc1cc(C)c(CNC(=O)c2csc(-c3cnn(C4CCNCC4)c3)c2C)c(=O)[nH]1

InChI Key InChIKey=FQDJHINNCRAOAE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 259346   

LigandChemical structure of BindingDB Monomer ID 259346BDBM259346(US9505745, 23 | US9790212, Example 23)
Affinity DataIC50: 501nMAssay Description:Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 259346BDBM259346(US9505745, 23 | US9790212, Example 23)
Affinity DataIC50: 501nMAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 259346BDBM259346(US9505745, 23 | US9790212, Example 23)
Affinity DataIC50: 3.98E+3nMAssay Description:Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 259346BDBM259346(US9505745, 23 | US9790212, Example 23)
Affinity DataIC50: 3.98E+3nMAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
US Patent