BDBM259577 US9505749, 88

SMILES O=C(CCc1nc2c(c(=O)[nH]1)CCCN2)N[C@H]1CC[C@H](c2nnc(-c3ccccc3)o2)CC1

InChI Key InChIKey=RXWZXVGCPOUNQT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 259577   

LigandChemical structure of BindingDB Monomer ID 259577BDBM259577(US9505749, 88)
Affinity DataIC50: 14.1nMAssay Description:The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 259577BDBM259577(US9505749, 88)
Affinity DataIC50: 37.1nMAssay Description:The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 259577BDBM259577(US9505749, 88)
Affinity DataIC50: 530nMAssay Description:PARP1 biochemical assay was purchased as a kit from Trevigen (cat.#4676-096-K) and used per manufacturers recommendations.PARP2 biochemical assay was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 259577BDBM259577(US9505749, 88)
Affinity DataIC50: 3.50E+3nMAssay Description:PARP1 biochemical assay was purchased as a kit from Trevigen (cat.#4676-096-K) and used per manufacturers recommendations.PARP2 biochemical assay was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
US Patent