BDBM26122 (2E)-but-2-enedioic acid::FUMARIC ACID::Fumarate::fumarate, 10

SMILES OC(=O)\C=C\C(O)=O

InChI Key InChIKey=VZCYOOQTPOCHFL-OWOJBTEDSA-N

Data  2 KI  4 IC50  2 Kd  1 ITC

PDB links: 63 PDB IDs match this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 26122   

TargetSolute carrier family 22 member 6(Mus musculus)
University Of California

Curated by ChEMBL
LigandPNGBDBM26122((2E)-but-2-enedioic acid | FUMARIC ACID | Fumarate...)
Affinity DataKi:  6.17E+5nMAssay Description:Inhibition of mouse Oat1-mediated [3H]PAH uptake in Xenopus oocytes after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 22 member 20(Mus musculus)
University Of California

Curated by ChEMBL
LigandPNGBDBM26122((2E)-but-2-enedioic acid | FUMARIC ACID | Fumarate...)
Affinity DataKi: >3.16E+7nMAssay Description:Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM26122((2E)-but-2-enedioic acid | FUMARIC ACID | Fumarate...)
Affinity DataIC50:  1.50E+5nMAssay Description:Inhibition of human hexahistidine-tagged full-length FTO expressed in Escherichia coli BL21 (DE3) using 3-methylthymidine as substrate assessed as in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl 4-hydroxylase(Paramecium bursaria Chlorella virus 1)
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM26122((2E)-but-2-enedioic acid | FUMARIC ACID | Fumarate...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of N-terminal His6-tagged recombinant Paramecium bursaria chlorella virus 1 CPH expressed in Escherichia coli Rosetta 2 (DE3) cells pre-in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM26122((2E)-but-2-enedioic acid | FUMARIC ACID | Fumarate...)
Affinity DataKd:  2.00E+5nMAssay Description:Binding affinity to human PHD2 catalytic domain (181 to 426) Mn2 expressed in Escherichia coli by NMR spectroscopic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethyl-accepting chemotaxis protein NahY(Pseudomonas putida (Arthrobacter siderocapsulatus))
Csic

LigandPNGBDBM26122((2E)-but-2-enedioic acid | FUMARIC ACID | Fumarate...)
Affinity DataKd:  1.70E+4nMT: 2°CAssay Description:Measurements were done on a VP-microcalorimeter (MicroCal, Amherst, MA).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4E(Homo sapiens (Human))
University Of Oxford

LigandPNGBDBM26122((2E)-but-2-enedioic acid | FUMARIC ACID | Fumarate...)
Affinity DataIC50:  1.60E+6nMpH: 7.5 T: 2°CAssay Description:A coupled-assay for JMJD2E activity employing formaldehyde dehydrogenase (FDH) from Pseudomonas putida was developed. Formaldehyde release by demethy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM26122((2E)-but-2-enedioic acid | FUMARIC ACID | Fumarate...)
Affinity DataIC50:  2.20E+5nMAssay Description:Inhibition of human PHD2 catalytic domain (181 to 426) Mn2 expressed in Escherichia coli by NMR spectroscopic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Activity Spreadsheet -- ITC Data from BindingDB

Found 1 hit for monomerid = 26122   

CellMethyl-accepting chemotaxis protein (McpS)(Pseudomonas putida (Arthrobacter siderocapsulatus))
Csic

SyringePNGBDBM26122((2E)-but-2-enedioic acid | FUMARIC ACID | Fumarate...)
ITC DataΔG°: -6.39kcal/mole −TΔS°: 7.00kcal/mole ΔH°: -13.3kcal/mole logk: 5.88E+4
T: 20.00°C 
In DepthDetails ArticlePubMed