BDBM262024 3-(2,6-difluoro-3,5-dimethoxyphenyl)-7-(1,3-dimethyl-1H-pyrazol-4-yl)-1-(1-propyl-1H-pyrazol-4-yl)-3,4-dihydropyrido[4,3-d]pyrimidin-2(1H)-one::US10251892, Example 132::US10632126, Example 132::US11173162, Example 132::US9708318, 132

SMILES CCCn1cc(cn1)N1C(=O)N(Cc2cnc(cc12)-c1cn(C)nc1C)c1c(F)c(OC)cc(OC)c1F

InChI Key InChIKey=AMILFCGKIUEALD-UHFFFAOYSA-N

Data  16 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 262024   

TargetFibroblast growth factor receptor 1(Human)
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US Patent

LigandBDBM262024(3-(2,6-difluoro-3,5-dimethoxyphenyl)-7-(1,3-dimeth...)Copy SMILESCopy InChI

Affinity DataIC50: 115nMAssay Description:FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...More data for this Ligand-Target Pair

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Date in BDB:
10/31/2018
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TargetFibroblast growth factor receptor 2(Human)
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LigandBDBM262024(3-(2,6-difluoro-3,5-dimethoxyphenyl)-7-(1,3-dimeth...)Copy SMILESCopy InChI

Affinity DataIC50: 20nMAssay Description:FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...More data for this Ligand-Target Pair

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10/31/2018
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TargetFibroblast growth factor receptor 3(Human)
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LigandBDBM262024(3-(2,6-difluoro-3,5-dimethoxyphenyl)-7-(1,3-dimeth...)Copy SMILESCopy InChI

Affinity DataIC50: 20nMAssay Description:FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Date in BDB:
10/31/2018
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TargetFibroblast growth factor receptor 4(Human)
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US Patent

LigandBDBM262024(3-(2,6-difluoro-3,5-dimethoxyphenyl)-7-(1,3-dimeth...)Copy SMILESCopy InChI

Affinity DataIC50: 115nMAssay Description:FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
10/31/2018
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TargetFibroblast growth factor receptor 1(Human)
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US Patent

LigandBDBM262024(3-(2,6-difluoro-3,5-dimethoxyphenyl)-7-(1,3-dimeth...)Copy SMILESCopy InChI

Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Date in BDB:
1/21/2020
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TargetFibroblast growth factor receptor 2(Human)
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LigandBDBM262024(3-(2,6-difluoro-3,5-dimethoxyphenyl)-7-(1,3-dimeth...)Copy SMILESCopy InChI

Affinity DataIC50: 20nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
1/21/2020
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TargetFibroblast growth factor receptor 3(Human)
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US Patent

LigandBDBM262024(3-(2,6-difluoro-3,5-dimethoxyphenyl)-7-(1,3-dimeth...)Copy SMILESCopy InChI

Affinity DataIC50: 20nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
1/21/2020
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TargetFibroblast growth factor receptor 4(Human)
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US Patent

LigandBDBM262024(3-(2,6-difluoro-3,5-dimethoxyphenyl)-7-(1,3-dimeth...)Copy SMILESCopy InChI

Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
1/21/2020
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TargetFibroblast growth factor receptor 1(Human)
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US Patent

LigandBDBM262024(3-(2,6-difluoro-3,5-dimethoxyphenyl)-7-(1,3-dimeth...)Copy SMILESCopy InChI

Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
1/10/2021
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TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent

LigandBDBM262024(3-(2,6-difluoro-3,5-dimethoxyphenyl)-7-(1,3-dimeth...)Copy SMILESCopy InChI

Affinity DataIC50: 20nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
1/10/2021
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TargetFibroblast growth factor receptor 3(Human)
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LigandBDBM262024(3-(2,6-difluoro-3,5-dimethoxyphenyl)-7-(1,3-dimeth...)Copy SMILESCopy InChI

Affinity DataIC50: 20nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Date in BDB:
1/10/2021
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TargetFibroblast growth factor receptor 4(Human)
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US Patent

LigandBDBM262024(3-(2,6-difluoro-3,5-dimethoxyphenyl)-7-(1,3-dimeth...)Copy SMILESCopy InChI

Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
1/10/2021
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TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent

LigandBDBM262024(3-(2,6-difluoro-3,5-dimethoxyphenyl)-7-(1,3-dimeth...)Copy SMILESCopy InChI

Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
4/3/2022
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TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent

LigandBDBM262024(3-(2,6-difluoro-3,5-dimethoxyphenyl)-7-(1,3-dimeth...)Copy SMILESCopy InChI

Affinity DataIC50: 20nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
4/3/2022
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TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent

LigandBDBM262024(3-(2,6-difluoro-3,5-dimethoxyphenyl)-7-(1,3-dimeth...)Copy SMILESCopy InChI

Affinity DataIC50: 20nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/3/2022
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TargetFibroblast growth factor receptor 4(Human)
Incyte

US Patent

LigandBDBM262024(3-(2,6-difluoro-3,5-dimethoxyphenyl)-7-(1,3-dimeth...)Copy SMILESCopy InChI

Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
4/3/2022
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