BDBM262446 3-(6-Aminopyridin-3-yl)-2-(1H-tetrazol-5-yl)benzene sulfonamide, TFA salt::US9708336, 298

SMILES Nc1ccc(cn1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O

InChI Key InChIKey=QGHCSGQFXJUCGF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 262446   

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM262446(US9708336, 298 | 3-(6-Aminopyridin-3-yl)-2-(1H-tet...)
Affinity DataIC50: 71.7nMpH: 7.0Assay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2018
Entry Details
Go to US Patent

TargetVIM-1 metallo-beta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM262446(US9708336, 298 | 3-(6-Aminopyridin-3-yl)-2-(1H-tet...)
Affinity DataIC50: 251nMpH: 7.0Assay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2018
Entry Details
Go to US Patent

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM262446(US9708336, 298 | 3-(6-Aminopyridin-3-yl)-2-(1H-tet...)
Affinity DataIC50: 776nMpH: 7.0Assay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2018
Entry Details
Go to US Patent