BDBM262489 4'-(morpholin-4-ylmethyl)-2- (1H-tetrazol-5-yl)biphenyl- 3-sulfonamide::US9708336, 341

SMILES NS(=O)(=O)c1cccc(-c2ccc(CN3CCOCC3)cc2)c1-c1nnn[nH]1

InChI Key InChIKey=KJKHNHKUVYLABS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 262489   

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM262489(US9708336, 341 | 4'-(morpholin-4-ylmethyl)-2- (1H-...)
Affinity DataIC50: 22.1nMpH: 7.0Assay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2018
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM262489(US9708336, 341 | 4'-(morpholin-4-ylmethyl)-2- (1H-...)
Affinity DataIC50: 2.94nMpH: 7.0Assay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2018
Entry Details
US Patent

TargetVIM-1 metallo-beta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM262489(US9708336, 341 | 4'-(morpholin-4-ylmethyl)-2- (1H-...)
Affinity DataIC50: 786nMpH: 7.0Assay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2018
Entry Details
US Patent