BDBM262770 N-[1-[5-[3-sulfamoyl-2-(1H- tetrazol-5-yl)phenyl]-2- pyridyl]pyrrolidin-3- yl]acetamide::US9708336, 623

SMILES CC(=O)NC1CCN(C1)c1ccc(cn1)-c1cccc(c1-c1nnn[nH]1)S(N)(=O)=O

InChI Key InChIKey=KJLSGAJHEVXQPR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 262770   

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 262770BDBM262770(N-[1-[5-[3-sulfamoyl-2-(1H- tetrazol-5-yl)phenyl]-...)
Affinity DataIC50: 7.94nMpH: 7.0Assay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2018
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 262770BDBM262770(N-[1-[5-[3-sulfamoyl-2-(1H- tetrazol-5-yl)phenyl]-...)
Affinity DataIC50: 79.5nMpH: 7.0Assay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2018
Entry Details
US Patent

TargetVIM-1 metallo-beta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 262770BDBM262770(N-[1-[5-[3-sulfamoyl-2-(1H- tetrazol-5-yl)phenyl]-...)
Affinity DataIC50: 207nMpH: 7.0Assay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2018
Entry Details
US Patent