BDBM263266 1-(6-phenoxy-pyridin-2-ylmethyl)-1h-pyrazole-4-carboxylic acid (1-amino-isoquinolin-6-ylmethyl)-amide::US9533987, example 47

SMILES Nc1nccc2cc(CNC(=O)c3cnn(Cc4cccc(Oc5ccccc5)n4)c3)ccc12

InChI Key InChIKey=IHOQTAVOKVKVJP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 263266   

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 263266BDBM263266(US9533987, example 47 | 1-(6-phenoxy-pyridin-2-ylm...)
Affinity DataIC50: 2.03E+3nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
US Patent

TargetKallikrein-1(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 263266BDBM263266(US9533987, example 47 | 1-(6-phenoxy-pyridin-2-ylm...)
Affinity DataIC50: 1.58E+4nMAssay Description:Human serine protease enzymes plasmin, thrombin, trypsin, Factor Xa and Factor XIIa were assayed for enzymatic activity using an appropriate fluoroge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
US Patent