BDBM263396 US9550741, II-6

SMILES O=S(=O)(N[C@H]1CC[C@H](CCN2CCN(CC2)c2nsc3ccccc23)CC1)c1c[nH]c2ccccc12

InChI Key InChIKey=QXEYNUWHIAFPHP-UHFFFAOYSA-N

Data  11 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 263396   

Target5-hydroxytryptamine receptor 1A(Human)
Shanghai Institute of Pharmaceutical Industry

US Patent
LigandPNGBDBM263396(US9550741, II-6)
Affinity DataKi:  0.580nMpH: 7.4Assay Description:1. Experimental Materials:The isotopic ligand of 5-H1A receptor [3H]0.8-OH-DPAT (purchased from PE Corporation), (+)5-hydroxytryptamine (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
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Target5-hydroxytryptamine receptor 2A(Human)
Shanghai Institute of Pharmaceutical Industry

US Patent
LigandPNGBDBM263396(US9550741, II-6)
Affinity DataKi:  1.47nMpH: 7.7Assay Description:1. Experimental Materials(1) 5-HT2A Cell Transfection:This experiment utilizes the plasmid vector containing the gene of the 5-HT2A receptor protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Shanghai Institute of Pharmaceutical Industry

US Patent
LigandPNGBDBM263396(US9550741, II-6)
Affinity DataKi:  1.47nMpH: 7.7Assay Description:1. Experimental Materials(1) 5-HT2A Cell Transfection:This experiment utilizes the plasmid vector containing the gene of the 5-HT2A receptor protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Shanghai Institute of Pharmaceutical Industry

US Patent
LigandPNGBDBM263396(US9550741, II-6)
Affinity DataKi:  2.36nMpH: 7.7Assay Description:1. Experimental Materials(1) 5-HT2A Cell Transfection:This experiment utilizes the plasmid vector containing the gene of the 5-HT2A receptor protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Shanghai Institute of Pharmaceutical Industry

US Patent
LigandPNGBDBM263396(US9550741, II-6)
Affinity DataKi:  2.36nMpH: 7.7Assay Description:1. Experimental Materials(1) 5-HT2A Cell Transfection:This experiment utilizes the plasmid vector containing the gene of the 5-HT2A receptor protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
Go to US Patent

TargetVitamin D3 receptor(Human)
Shanghai Institute of Pharmaceutical Industry

US Patent
LigandPNGBDBM263396(US9550741, II-6)
Affinity DataKi:  2.76nMAssay Description:The experiment is carried out by the method according to Journal of Pharmacology and Experimental Therapeutics 2010, 333(1): 328. With [3H]methyl-spi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
Go to US Patent

TargetVitamin D3 receptor(Human)
Shanghai Institute of Pharmaceutical Industry

US Patent
LigandPNGBDBM263396(US9550741, II-6)
Affinity DataKi:  2.76nMAssay Description:The experiment is carried out by the method according to Journal of Pharmacology and Experimental Therapeutics 2010, 333(1): 328. With [3H]methyl-spi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
Go to US Patent

TargetD(2) dopamine receptor(Human)
Shanghai Institute of Pharmaceutical Industry

US Patent
LigandPNGBDBM263396(US9550741, II-6)
Affinity DataKi:  3.62nMpH: 7.5Assay Description:1. Experimental Materials:(1) D2 receptor Cell Transfection:This experiment utilizes the plasmid vector containing the gene of D2 receptor protein fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
Go to US Patent

TargetD(2) dopamine receptor(Human)
Shanghai Institute of Pharmaceutical Industry

US Patent
LigandPNGBDBM263396(US9550741, II-6)
Affinity DataKi:  3.62nMpH: 7.5Assay Description:1. Experimental Materials:(1) D2 receptor Cell Transfection:This experiment utilizes the plasmid vector containing the gene of D2 receptor protein fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 1A(Human)
Shanghai Institute of Pharmaceutical Industry

US Patent
LigandPNGBDBM263396(US9550741, II-6)
Affinity DataKi:  17.1nMpH: 7.4Assay Description:1. Experimental Materials:The isotopic ligand of 5-H1A receptor [3H]0.8-OH-DPAT (purchased from PE Corporation), (+)5-hydroxytryptamine (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 1A(Human)
Shanghai Institute of Pharmaceutical Industry

US Patent
LigandPNGBDBM263396(US9550741, II-6)
Affinity DataKi:  17.1nMpH: 7.4Assay Description:1. Experimental Materials:The isotopic ligand of 5-H1A receptor [3H]0.8-OH-DPAT (purchased from PE Corporation), (+)5-hydroxytryptamine (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
Go to US Patent