BDBM263576 US10238633, Example 5::US9713606, 5

SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-n1cc(nn1)-c1ccc2[nH]ccc2c1

InChI Key InChIKey=JKQDJXYFEPRJDZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 263576   

TargetDipeptidyl peptidase 1(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM263576(US9713606, 5 | US10238633, Example 5)
Affinity DataIC50: 4nMpH: 6.0 T: 2°CAssay Description:Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent

TargetDipeptidyl peptidase 1(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM263576(US9713606, 5 | US10238633, Example 5)
Affinity DataIC50: 4nMAssay Description:The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 μg/ml, respectively), and then activated by mixing in a 1:2 ratio with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

TargetCathepsin K(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM263576(US9713606, 5 | US10238633, Example 5)
Affinity DataIC50: 2.60E+3nMpH: 3.5 T: 2°CAssay Description:Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent

TargetCathepsin K(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM263576(US9713606, 5 | US10238633, Example 5)
Affinity DataIC50: 2.60E+3nMAssay Description:To activate the proenzyme, 5 μl procathepsin K were mixed with 1 ul activation buffer, and incubated at room temperature for 30 min.5 μL te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent