BDBM263946 2-(5-(3-fluorophenyl)-1H-pyrazol- 1-yl)isonicotinic acid::US10173996, Example 16::US9604961, Example 16::US9714230, 16::US9908865, Example 16

SMILES OC(=O)c1ccnc(c1)-n1nccc1-c1cccc(F)c1

InChI Key InChIKey=QKDWURZWFKZKLH-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 263946   

TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM263946(2-(5-(3-fluorophenyl)-1H-pyrazol- 1-yl)isonicotini...)
Affinity DataIC50: 500nMAssay Description:Inhibition of KDM5B (unknown origin) preincubated with enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM263946(2-(5-(3-fluorophenyl)-1H-pyrazol- 1-yl)isonicotini...)
Affinity DataIC50: 550nMAssay Description:The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
Go to US Patent

TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM263946(2-(5-(3-fluorophenyl)-1H-pyrazol- 1-yl)isonicotini...)
Affinity DataIC50: 550nMAssay Description:The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
Go to US Patent

TargetLysine-specific demethylase 5A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM263946(2-(5-(3-fluorophenyl)-1H-pyrazol- 1-yl)isonicotini...)
Affinity DataIC50: 550nMAssay Description:The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
Go to US Patent

TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM263946(2-(5-(3-fluorophenyl)-1H-pyrazol- 1-yl)isonicotini...)
Affinity DataIC50: 660nMAssay Description:Inhibition of KDM4C (unknown origin) preincubated with enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed