BDBM26670 2,3-diphenyl-1H-indole-7-carboxylic acid::cid_5003498::diphenylindole carboxylic acid, 3

SMILES OC(=O)c1cccc2c(c([nH]c12)-c1ccccc1)-c1ccccc1

InChI Key InChIKey=OLUDUXWVPIEHDA-UHFFFAOYSA-N

Data  1 KI  1 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 26670   

TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM26670(2,3-diphenyl-1H-indole-7-carboxylic acid | cid_500...)
Affinity DataKi:  550nM ΔG°:  -8.68kcal/molepH: 7.6 T: 2°CAssay Description:A coupled-enzyme assay was used to quantify the ADP generated in the kinase reaction with S6 peptide (RRRLSSLRA) as the phosphoacceptor substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM26670(2,3-diphenyl-1H-indole-7-carboxylic acid | cid_500...)
Affinity DataIC50:  550nMAssay Description:Inhibition of human Pim-1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate preincubated for 15 mins prior substrate addition measured after 45 mins by fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStreptokinase A(Streptococcus pyogenes M1 GAS)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM26670(2,3-diphenyl-1H-indole-7-carboxylic acid | cid_500...)
Affinity DataEC50:  1.56E+4nMAssay Description:Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay