BDBM267202 N-[2-(4-cyclopropyl-1,3-thiazol-5-yl)-2-(4,4-difluoropiperidin-1-yl)ethyl]quinoline-5-carboxamide::US10167281, Compound 121::US9718812, 121

SMILES FC1(F)CCN(CC1)C(CNC(=O)c1cccc2ncccc12)c1scnc1C1CC1

InChI Key InChIKey=HNBKKJRIQIOELO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 267202   

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandPNGBDBM267202(N-[2-(4-cyclopropyl-1,3-thiazol-5-yl)-2-(4,4-diflu...)
Affinity DataIC50: 531nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandPNGBDBM267202(N-[2-(4-cyclopropyl-1,3-thiazol-5-yl)-2-(4,4-diflu...)
Affinity DataIC50: 531nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2018
Entry Details
US Patent