BDBM2711 3-(1,2,3,4-Tetrahydropyrazino[1,2-a]indol-10-yl)-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione::3-(1-methyl-1H-indol-3-yl)-4-{1H,2H,3H,4H-pyrazino[1,2-a]indol-10-yl}-2,5-dihydro-1H-pyrrole-2,5-dione::Bisindolylmaleimide deriv. 17::ROCHE screening, 63

SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CNCCn3c3ccccc23)c2ccccc12

InChI Key InChIKey=WGLDKILPHLGLGQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 2711   

TargetProtein kinase C beta type(Rattus norvegicus (rat))
Roche Products

LigandPNGBDBM2711(3-(1,2,3,4-Tetrahydropyrazino[1,2-a]indol-10-yl)-4...)
Affinity DataIC50:  540nMAssay Description:The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Technical University of Dortmund

LigandPNGBDBM2711(3-(1,2,3,4-Tetrahydropyrazino[1,2-a]indol-10-yl)-4...)
Affinity DataIC50: >2.00E+4nMAssay Description:IC50 determinations for TBK1 were performed with the KinEASE-STK assay from Cisbio according to the manufacturer's instructions. A biotinylated s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Roche Products

LigandPNGBDBM2711(3-(1,2,3,4-Tetrahydropyrazino[1,2-a]indol-10-yl)-4...)
Affinity DataIC50:  3.20E+3nMAssay Description:The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed