BDBM2719 1-(5-chloropyridin-2-yl)-3-[2-(3-acetyl-6-fluoro-2-methoxyphenyl)ethyl]urea::N-[2-(3-Acetyl-6-fluoro-2-methoxyphenethyl)]-N-[2-(5-chloropyridy)]urea::urea-PETT deriv. 4

SMILES COc1c(CCNC(=O)Nc2ccc(Cl)cn2)c(F)ccc1C(C)=O

InChI Key InChIKey=CZVZTRQYAQOLCN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 2719   

TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Medivir

LigandPNGBDBM2719(1-(5-chloropyridin-2-yl)-3-[2-(3-acetyl-6-fluoro-2...)
Affinity DataIC50: 224nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,Y768C]/[588-1147,Y768C](Human immunodeficiency virus type 1)
Medivir

LigandPNGBDBM2719(1-(5-chloropyridin-2-yl)-3-[2-(3-acetyl-6-fluoro-2...)
Affinity DataIC50: 1.27E+4nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027,K690N]/[588-1147,K690N](Human immunodeficiency virus type 1)
Medivir

LigandPNGBDBM2719(1-(5-chloropyridin-2-yl)-3-[2-(3-acetyl-6-fluoro-2...)
Affinity DataIC50: 2.70E+3nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2004
Entry Details Article
PubMed