BDBM272148 E1-(abs)-6-(3-Fluoro-2-methylphenyl)-N-hydroxy-2- (2,2,2-trifluoroethyl)-2,4,5,6,7,8- hexahydrocyclohepta[c]pyrazole-6-carboxamide::US10065948, 84::US10065948, 85::US10457675, Example 85

SMILES Cc1c(F)cccc1C1(CCc2cn(CC(F)(F)F)nc2CC1)C(=O)NO

InChI Key InChIKey=LDNRWGUDNLEHMR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 272148   

TargetHistone deacetylase 9(Human)
Chdi Foundation

US Patent
LigandPNGBDBM272148(US10065948, 85 | E1-(abs)-6-(3-Fluoro-2-methylphen...)
Affinity DataIC50: 480nMAssay Description:The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
Go to US Patent

TargetHistone deacetylase 9(Human)
Chdi Foundation

US Patent
LigandPNGBDBM272148(US10065948, 85 | E1-(abs)-6-(3-Fluoro-2-methylphen...)
Affinity DataIC50: 480nMAssay Description:The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 9(Human)
Chdi Foundation

US Patent
LigandPNGBDBM272148(US10065948, 85 | E1-(abs)-6-(3-Fluoro-2-methylphen...)
Affinity DataIC50: 790nMAssay Description:The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
Go to US Patent

TargetHistone deacetylase 9(Human)
Chdi Foundation

US Patent
LigandPNGBDBM272148(US10065948, 85 | E1-(abs)-6-(3-Fluoro-2-methylphen...)
Affinity DataIC50: 790nMAssay Description:The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent