BDBM272543 3-(2-methylpyridin-4-yl)-5,6,7,9-tetrahydroazepino[3,2-f]indazol-8(1H)-one::US10065967, Example 9::US10759805, Ex 9::US9745307, Example 9

SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)CCCc3cc12

InChI Key InChIKey=YWGRWRNTWJLNLC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 272543   

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM272543(3-(2-methylpyridin-4-yl)-5,6,7,9-tetrahydroazepino...)
Affinity DataIC50: 252nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM272543(3-(2-methylpyridin-4-yl)-5,6,7,9-tetrahydroazepino...)
Affinity DataIC50: 252nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM272543(3-(2-methylpyridin-4-yl)-5,6,7,9-tetrahydroazepino...)
Affinity DataIC50: 2.52E+5nMAssay Description:Human: Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2021
Entry Details
US Patent