BDBM273196 (R)-N-benzyl-1-(3-methyl-4-oxo-2-trifluoromethyl-3,4-dihydropyrido[3,2-d]pyrimidin-6-yl)pyrrolidine-2-carboxamide::US10065972, Example 707

SMILES Cn1c(nc2ccc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1ccccc1)C(F)(F)F

InChI Key InChIKey=WUEPAIYWKGRKRV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 273196   

TargetKynurenine/alpha-aminoadipate aminotransferase, mitochondrial(Human)
Mitsubishi Tanabe Pharma

US Patent
LigandPNGBDBM273196((R)-N-benzyl-1-(3-methyl-4-oxo-2-trifluoromethyl-3...)
Affinity DataIC50: 680nMpH: 8.0Assay Description:The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent