BDBM274234 6-(4-chlorophenyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-(3,8-dimethyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-1-methyl-5,6-dihydropyrrolo[3,4-b]pyrrol-4(1H)-one::US9550796, Example 31

SMILES Cc1nnc2c(C)cc(cn12)N1C(c2c(cc(C3=CCOCC3)n2C)C1=O)c1ccc(Cl)cc1

InChI Key InChIKey=SMYPWBHABVYAJK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 274234   

TargetBromodomain-containing protein 4 [44-477](Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 274234BDBM274234(6-(4-chlorophenyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5...)
Affinity DataIC50: 36nMpH: 7.5Assay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetBromodomain-containing protein 3(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 274234BDBM274234(6-(4-chlorophenyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5...)
Affinity DataIC50: 47nMpH: 7.5Assay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetBromodomain-containing protein 2 [60-463](Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 274234BDBM274234(6-(4-chlorophenyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5...)
Affinity DataIC50: 62nMpH: 7.5Assay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetCREB-binding protein(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 274234BDBM274234(6-(4-chlorophenyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5...)
Affinity DataIC50: 3.10E+3nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent