BDBM274281 5-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)-6-(4-fluorophenyl)-1-methyl-5,6-dihydropyrrolo[3,4-b]pyrrol-4(1H)-one::US9550796, Example 82

SMILES Cc1cc(cn(C)c1=O)N1C(c2c(ccn2C)C1=O)c1ccc(F)cc1

InChI Key InChIKey=RFBMWIYVIXUMRE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 274281   

TargetBromodomain-containing protein 3(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 274281BDBM274281(5-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)-6-(...)
Affinity DataIC50: 140nMpH: 7.5Assay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetBromodomain-containing protein 4 [44-477](Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 274281BDBM274281(5-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)-6-(...)
Affinity DataIC50: 195nMpH: 7.5Assay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetBromodomain-containing protein 2 [60-463](Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 274281BDBM274281(5-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)-6-(...)
Affinity DataIC50: 230nMpH: 7.5Assay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetCREB-binding protein(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 274281BDBM274281(5-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)-6-(...)
Affinity DataIC50: 4.70E+3nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent