BDBM274282 4-(5-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)-1-methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4-b]pyrrol-6-yl)benzonitrile::US9550796, Example 83

SMILES Cc1cc(cn(C)c1=O)N1C(c2c(ccn2C)C1=O)c1ccc(cc1)C#N

InChI Key InChIKey=VBWJYWJSBHIBOW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 274282   

TargetBromodomain-containing protein 3(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 274282BDBM274282(4-(5-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)-...)
Affinity DataIC50: 200nMpH: 7.5Assay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetBromodomain-containing protein 2 [60-463](Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 274282BDBM274282(4-(5-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)-...)
Affinity DataIC50: 273nMpH: 7.5Assay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetBromodomain-containing protein 4 [44-477](Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 274282BDBM274282(4-(5-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)-...)
Affinity DataIC50: 322nMpH: 7.5Assay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetCREB-binding protein(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 274282BDBM274282(4-(5-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)-...)
Affinity DataIC50: 7.15E+3nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent