BDBM274320 6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-1-methyl-2-(tetrahydro-2H-pyran-4-yl)-5,6-dihydropyrrolo[3,4-b]pyrrol-4(1H)-one::US9550796, Example 121

SMILES Cc1nnc2c(C)cc(cn12)N1C(c2c(cc(C3CCOCC3)n2C)C1=O)c1ccc(Cl)cc1

InChI Key InChIKey=HXGQYSSCVKIEIA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 274320   

TargetBromodomain-containing protein 3(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 274320BDBM274320(6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]triazolo...)
Affinity DataIC50: 44nMpH: 7.5Assay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetBromodomain-containing protein 4 [44-477](Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 274320BDBM274320(6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]triazolo...)
Affinity DataIC50: 56nMpH: 7.5Assay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetCREB-binding protein(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 274320BDBM274320(6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]triazolo...)
Affinity DataIC50: 640nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent