BDBM275390 1-[(3S,4S)-1-(2,6- difluorobenzyl)-4- methoxypyrrolidin-3-yl]-3-[1- (2-methylpyridin-4-yl)-1H- pyrazolo[3,4-c]pyridin-5- yl]urea::US9884048, Example 269::US9884048, Example 273::US9884048, Example 274

SMILES CO[C@H]1CN(Cc2c(F)cccc2F)C[C@@H]1NC(=O)Nc1cc2cnn(-c3ccnc(C)c3)c2cn1

InChI Key InChIKey=FCCDPKRNUKFKCM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 275390   

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM275390(1-[(3S,4S)-1-(2,6- difluorobenzyl)-4- methoxypyrro...)
Affinity DataIC50: 3.54nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM275390(1-[(3S,4S)-1-(2,6- difluorobenzyl)-4- methoxypyrro...)
Affinity DataIC50: 5.39nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM275390(1-[(3S,4S)-1-(2,6- difluorobenzyl)-4- methoxypyrro...)
Affinity DataIC50: 2.06E+3nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent